What are Barbiturates?
Barbiturates are a class of medications which are central nervous system depressants. They work by limiting the ability of gamma-aminobutyric acid, a neurotransmitter, which enables nerves to communicate with one another. Administering the drug thus makes it harder for neurons to fire, creating a tranquilizing effect in the patient.
Doctors rarely prescribe barbiturates anymore. Getting the dose exactly right can be difficult to predict, and if the dose is too strong, it can result in coma, or death. This has led to a track record of overdoses, causing doctors to favor benzodiazepines in situations that require a tranquilizing agent.
However, barbiturates still have practical uses. By reducing nervous system activity, barbiturates function as a muscle relaxant or an anticonvulsant. This makes them helpful for treating seizures, insomnia, or headaches. They are also used to sedate patients during operations, to put down animals, or for capital punishment.
Common barbiturates (and their brand names) are:
Amobarbital (Amytal), Butabarbital (Butisol), Pentobarbital (Nembutal), Secobarbital (Seconal), Phenobarbital (Luminal), Mephobarbital (Mebaral)